Shanghai Zhuoyi Technology - Supplier of Preclinical Small Animal Focused Ultrasound Systems

We utilize the RK50 small animal focused ultrasound system combined with nanobubble technology to achieve reversible blood-brain barrier opening, significantly enhancing the delivery efficiency of low-density lipoprotein-based nanoparticles to glioblastoma sites and paving a new path for brain tumor treatment.

—— UT Southwestern Medical Center, Enhanced Delivery of Low-Density Lipoprotein-Based Nanoparticles to Mouse Glioblastoma Using Focused Ultrasound as a Novel TherapyBiomaterials, https://doi.org/10.1016/j.biomaterials.2026.124198 (2026).

We performed key experiments using the RK50 small-animal focused ultrasound system, revealing a novel mechanism by which α-synuclein in red blood cells crosses the blood-brain barrier. This provides new insights into the pathogenesis of neurodegenerative diseases such as Parkinson's disease.

—— Z. Zhang, B. Cheng, et al., Parkinson's Disease Beyond the Brain: Erythrocyte α-Synuclein Transfer Across the Blood–Brain BarrierBrain, https://doi.org/10.1093/brain/awag179 (2026).

Combining focused ultrasound with nanobubbles enables precise, reversible, and safe delivery of large-molecule antibody drugs to small brain targets (e.g., the lateral habenula), offering a new low-side-effect treatment for brain disorders such as depression. This technology improves delivery accuracy by approximately fourfold, and after a single dose, the drug remains in the brain for 10 days, with therapeutic effects lasting at least 2 weeks.

—— W. Li, J. Hu, B. Cheng, et al., Precise antibody delivery to the brain via nanobubble-actuated focused ultrasound alleviates depressionProc. Natl. Acad. Sci. U.S.A.122 (35) e2421800122, https://doi.org/10.1073/pnas.2421800122 (2025).

The N1 peptide we discovered efficiently and specifically delivers biomacromolecules such as fluorescent dyes and genome-editing proteins directly into the cytoplasm and nucleus of neurons. When combined with focused ultrasound to open the blood-brain barrier, it establishes a new universal platform for in vivo super-resolution imaging and neuronal genome editing.

—— X. Ge, Z. Qin, et al., In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super-Resolution Imaging and Genome Editing.Adv. Sci.2025, 12, 2501033. https://doi.org/10.1002/advs.202501033

By combining focused ultrasound-mediated blood-brain barrier opening with long-circulating nanoparticles, we achieved efficient, systemic delivery of nucleic acids and gene editing tools to specific brain regions. This platform precisely delivers mRNA and CRISPR-based gene editing components to neurons and astrocytes. In contrast, traditional lipid nanoparticles (such as clinically relevant platforms) fail to achieve this due to short circulation times or poor serum stability.

— Gijung Kwak, Jung Soo Suk, et al., Brain Nucleic Acid Delivery and Genome Editing via Focused Ultrasound-Mediated Blood–Brain Barrier Opening and Long-Circulating NanoparticlesACS Nano2024 18 (35), 24139-24153, DOI: 10.1021/acsnano.4c05270

We introduce REMIS, a novel paradigm that uses focused ultrasound to open the blood-brain barrier and noninvasively release engineered protein markers from neurons into the bloodstream. This enables cell-type-, spatial-, and temporal-specific monitoring of gene expression and signaling pathways in the living brain through a single ultrasound session followed by a simple blood test. REMIS establishes a reliable new method for noninvasive assessment of intracranial gene delivery and endogenous signaling.

—— Seo JP, Trippett JS, Huang Z, Lee S, Nouraein S, Wang RZ, Szablowski JO. Acoustically targeted measurement of transgene expression in the brain.Sci Adv.2024 Aug 9;10(32):eadj7686. doi: 10.1126/sciadv.adj7686. Epub 2024 Aug 7. PMID: 39110811; PMCID: PMC11305388.

We combined focused ultrasound with nanodroplets loaded with pentobarbital, successfully lowering blood pressure in hypertensive rats to healthy levels. After five consecutive days of treatment, the antihypertensive effect persisted for up to four days. This strategy works by activating inhibitory GABAergic neuron pathways in the periaqueductal gray matter of the brain. The acoustic signals generated by ultrasound-induced droplet vaporization correlated with both the magnitude of blood pressure reduction and neuronal activity, offering a promising new approach for noninvasive, home-based management of resistant hypertension.

Lea-Banks H, Chauhan N, Hynynen K. Investigating the hypotensive effect of focused ultrasound neuromodulation and barbiturate-loaded nanodroplets in healthy and hypertensive rats.Brain Stimulation 2024; 17, 1317-1327.