Shanghai Zhuoyi Technology - Supplier of Preclinical Small Animal Focused Ultrasound Systems

In 2026, 6, researchers at UT Southwestern Medical Center in Dallas, Texas, leveraged our RK50 tabletop focused ultrasound system to achieve a significant breakthrough in glioblastoma treatment. The findings were published in a top-tier journal in biomaterials.Biomaterials。

Research Background

Glioblastoma (GBM) is the most aggressive primary brain tumor, with a very poor prognosis. The blood-brain barrier severely limits the delivery efficiency of chemotherapy drugs, resulting in suboptimal treatment outcomes. Developing drug delivery strategies capable of effectively crossing the blood-brain barrier has become a critical challenge that urgently needs to be addressed in this field.

Technological Innovation

The research team utilized the RK50 focused ultrasound system combined with microbubble technology to achieve reversible opening of the blood-brain barrier, significantly enhancing chemotherapy drug accumulation at the tumor site.

• Use the RK50 system for precise blood-brain barrier opening with sub-millimeter localization accuracy.
• Real-time monitoring of cavitation signals via acoustic feedback to ensure treatment safety.
• Combined nanobubble contrast agents to enhance blood-brain barrier opening
• Significantly increase drug concentration in tumor tissue while reducing systemic toxicity

Key Findings

Research shows that blood-brain barrier opening mediated by RK50 can:

• Increase the concentration of chemotherapy drugs at the tumor site by 3-5 times.
• Significantly prolongs survival in tumor-bearing mice
• Reduce tumor recurrence and metastasis
• No obvious neurotoxicity or long-term side effects were observed.

Core advantages of the RK50 system

The RK50 Desktop Small Animal Focused Ultrasound System demonstrated unique technical advantages in this study:

• Precision targeting:Phased array transducers achieve millimeter-level focusing for precise tumor targeting.
• Real-time Monitoring:Passive cavitation detection system with real-time feedback and automatic ultrasound parameter adjustment
• High repeatability:Integrated design ensures consistent experimental conditions and reliable data.
• Easy to useGraphical user interface with standardized workflows to reduce learning costs.
• Secure and reliable:Multiple security safeguards to ensure animal welfare and experimental success

Clinical translation prospects

This study provides a new strategy for glioblastoma treatment with significant clinical translation potential. Currently, focused ultrasound-mediated blood-brain barrier opening has entered clinical trials and is expected to be applied in patient care within the next few years.