RK-50 Desktop Small Animal Focused Ultrasound System
Integrated Focused Ultrasound Platform: Delivering Stable, Reliable Experimental Support for Neuroscience Research
Product Overview
RK-50 Desktop Small Animal Focused Ultrasound System, combined with a 3D brain atlas, enables precise delivery of ultrasound energy to the rodent brain. By integrating a 3D stereotaxic frame, an ultrasound drive system, and acoustic feedback algorithms, RK50 achieves noninvasive blood-brain barrier opening, transcranial neuromodulation, and sonodynamic therapy with high precision.
The device features an integrated desktop design with a compact structure and easy operation. Suitable for various laboratory animal models, including mice and rats, it provides researchers with a stable and reproducible experimental platform.
Inquire about this productRK-50 System Components
RK-50 Host
- Integrated 3D stereotactic brain instrument with high-precision robotic arm for sub-millimeter positioning accuracy.
- Compatible with rat and mouse brain atlases; seamlessly integrates with standard neuroscience platforms.
- Multi-degree-of-freedom adjustment; import other medical images (e.g., MRI) for target localization
- Compatible with anesthesia systems and animal temperature monitoring platforms to improve experimental success rates.
Integrated Ultrasound Drive System
- Integrated ultrasound drive, plug-and-play
- Comes with a desktop PC for rapid hardware response
- Customizable impedance matching circuit for a single transducer with multi-frequency drive
Ultrasonic Transducers and Acoustic Feedback Systems
- Customizable ultrasonic transducers for diverse application needs
- Provides a sound pressure calibration curve for clearer parameters.
- Passive cavitation detection probe for real-time acoustic signal acquisition and precise blood-brain barrier status assessment
Product Advantages
All-in-one integrated system
RK50 integrates three core modules—ultrasonic driving, stereotactic guidance, and acoustic feedback—into a single platform, eliminating the need to purchase and assemble multiple devices. Fully calibrated and tested before shipment, the system is ready to use out of the box, significantly reducing equipment setup and maintenance costs.
- • Integrated design saves lab space
- • Pre-calibration system to reduce setup time
- • Unified software control for streamlined operations
Efficient Experiment Workflow
From animal immobilization and target localization to ultrasound intervention, RK50 delivers a complete standardized workflow. With preconfigured experimental protocol templates, researchers can open the blood-brain barrier in a single animal within 30 minutes, significantly boosting experimental throughput.
- • Standardize workflows to reduce human error
- • Rapid animal restraint system to reduce setup time
- • Batch experiment data management for easier downstream analysis
Acoustic Feedback
Built-in passive cavitation detection system monitors microbubble activity in real time. By analyzing harmonic and ultraharmonic signals, the system automatically assesses blood-brain barrier opening levels and immediately halts ultrasound output upon detecting inertial cavitation to ensure experimental safety.
- • Real-time cavitation signal monitoring and display
- • Automatic safety threshold control
- • Post-Experiment Cavitation Data Analysis Report
Flexible Target Mode and Technical Support
Supports single-target, multi-target, and grid scan intervention modes to meet diverse research needs. Provides systematic training and experimental protocol consultation to facilitate smooth research execution.
- • Multiple target modes available (single-point, multi-point, scan)
- • Support for customized experimental protocol development
Add-on product: RK-20 Ultrasound Platform
RK-50 Lite – Compatible with most standard laboratory stereotaxic instruments. A more cost-effective choice.
Product Positioning
RK-20 is a streamlined version of RK-50, which does not include the control unit or 3D stereotaxic apparatus by default. For laboratories that already have a stereotaxic system or focus on peripheral nerve research, RK-20 offers a more cost-effective solution.
- Optimized provisioning to reduce procurement costs
- Compact integrated system designed for specific research needs
- Can be upgraded to the full RK-50 system later.
RK-20 vs. RK-50 Configuration Comparison
| Configuration | RK-20 | RK-50 |
|---|---|---|
| Ultrasonic Drive System | ✓ | ✓ |
| Ultrasound Transducer | ✓ | ✓ |
| Acoustic Feedback System | ✗ | ✓ |
| Control Host | ✓ | ✓ |
| 3D Brain Stereotaxic Instrument | ✗ | ✓ |
| Rat/Mouse Brain Atlas | ✗ | ✓ |
Use Cases
Blood-brain barrier opening
Reversibly opening the blood-brain barrier using focused ultrasound combined with microbubble contrast agents, offering a new therapeutic approach for central nervous system diseases.
Targeted Drug Delivery
Precisely deliver therapeutic drugs to specific brain regions, increase local drug concentration, and reduce systemic side effects.
Transcranial Neuromodulation
Non-invasively modulate neural activity, study neural circuit function, and explore new treatments for neurological disorders.
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