Shanghai Zhuoyi Technology - Supplier of Preclinical Small Animal Focused Ultrasound Systems

Nano-bubble Contrast Agents

High-efficiency, stable contrast agent providing reliable support for blood-brain barrier opening

Nano-bubble Contrast Agents

Product Overview

The NanoBubble Contrast Agent is a high-efficiency contrast agent designed for ultrasound-mediated blood-brain barrier (BBB) opening research and also suitable for high-resolution ultrasound imaging. Produced using advanced fabrication technology, it features uniform particle size and excellent stability. Under ultrasound exposure, it generates stable cavitation effects, significantly improving the accuracy and reproducibility of BBB opening.

Nanobubbles exhibit excellent biocompatibility and safety, making them widely used in cutting-edge research areas such as Alzheimer's disease, brain tumors, and gene therapy.

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Core Technical Specifications

Nanobubble Microstructure

Particle size range

170-200 nm, uniform particle size, capable of passing through capillaries

Stability

Once activated, refrigeration maintains stability for approximately 8 hours, meeting experimental workflow requirements.

biocompatibility

Excellent biocompatibility, high safety profile, and minimal side effects

Use Cases

Blood-brain barrier opening, enhanced ultrasound imaging, and drug delivery

Nano-bubble Applications

Mechanism of Action

Ultrasound Response

Generate stable vibrations under focused ultrasound to produce mechanical effects.

Barrier Open

Microbubble vibrations temporarily loosen tight junctions between cerebral vascular endothelial cells, enabling reversible opening of the blood-brain barrier.

Auto-recovery

Blood-brain barrier automatically restores within hours, ensuring high safety and no disruption to normal physiological functions.

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